Evaluation of the current treatment strategies for poorly differentiated pancreatic neuroendocrine tumors

Presenter: Jamie Glasser MS | Sarasota Memorial Cancer Institute Background: The management of pancreatic neuroendocrine tumors (PNET) varies between observation (O), resection (PR) and enucleation (E). Currently, size, grade location are used to determine which treatment strategy may be employed. We sought evaluate each further clarify the role for surgery with regards patients poorly differentiated (PD) PNET. Methods: Utilizing National Database we identified stratified based upon size management. Mann-Whitney U Kruskal were compare continuous variables Pearson’s Chi-square test was categorical variables. Unadjusted survival analyses performed using Kaplan-Meier method. Multivariate analysis (MVA) identify predictors survival. All statistical tests two-sided p<0.05 considered significant. Results: 3,187 PD PNET a median age 61 (18-90). There 84 (2.6%) 2 cm. more males than females p2cm demonstrated higher incidence node positivity compared other cohorts, p2cm, p=0.01. Patients 2cm tumors, 5-year 65% in those undergoing vs 16% who did not, p<0.001. no difference resection, (median 102.2 months PR, 107.9 PE, p=0.16). revealed age, tumor location, surgery, clinical stage Conclusion: Poorly exhibit high positivity, even < 1cm. Surgery improves all Thus, has